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Up to 50 years of XX century to the Generic Sinemet include two groups of low-molecular compounds: amines (acetylcholine, adrenaline, noradrenaline, serootonin, dopamine) and amino acids (gamma-aminobutyric acid, glutamate, aspartate, glycine). Later it was shown that a specific group of neuropeptides are Sinemet, which can act also as neuromodulators (substances that alter the magnitude of the response of a neuron to a stimulus). It is now known that neurons can synthesize and release several neurotransmitters (coexisting neurotransmitters). Such a representation of the chemical coding part of the basis of the principle of plurality of chemical synapses. Sinemet uses neuromediator has plasticity, that is, able to change the main mediator in the development process. The combination of mediators may be different for different synapses.
In the nervous system, there are special nerve cells - neurosecretory. They have the typical structural and functional (ie, the ability to conduct nerve impulses), neuronal organization, and their specific feature is the neurosecretory function associated with the secretion of biologically active substances. The functional significance of this mechanism is to ensure that the regulatory chemical communication between the central nervous and endocrine systems, carried out by neyrosekretiruemyh products. In the evolution of cells belonging to the primitive nervous systems, specializing in two directions: Carbidopa and Levodopa. In the evolution of cells, combining sensory, and secretory function of conductor, formed specialized neurons, including neurosecretory.
Consequently, there were no neurosecretory cells of the neuron itself, but from their common ancestor - Sinemet 10/100. The evolution of neurosecretory cells has led to the formation of them, like the classical neurons, the ability to process synaptic excitation and inhibition of action potential generation.

